Oral Roberts became just the second No. 15 seed to advance to the round of 16 by stunning No. 7 seed Florida 81-78.
Kevin Obanor and Max Abams carried the Golden Eagles to their second straight upset of the NCAA tournament.
Oral Roberts beat No. 2 seed Ohio State in the first round.
Obanor scored 28 points and Abmas finished with 26 as the Golden Eagles overcame an 11-point deficit.
Oral Roberts joins Florida Gulf Coast as the only No. 15 seeds to reach the round of 16.
The Golden Eagles play No. 3 seed Arkansas next.